• 1\. Male/female 18 years of age or older at the time of screening. 2. Voluntarily signed informed consent, understand the study and are willing to follow and have the ability to complete all trial procedures.

• 3\. Subjects with histologically or cytologically pathologically confirmed locally advanced unresectable or metastatic solid tumors that have failed standard therapy or have no standard therapy. There is no limit to the number of treatments that can be used in a previous regimen.

• 4\. ECOG performance status 0 or 1. 5. Expected survival ≥ 3 months. 6. Participants enrolled in Phase 2 must have at least one measurable (RECIST v1.1 criteria) lesion, and participants enrolled in Phase 1 may also be enrolled if only non-measurable (RECIST v1.1 criteria) lesions are present. Neoplastic lesions located in the field of prior radiation therapy or treated with other local therapies are not considered measurable unless disease progression has been demonstrated.

• 7\. Phase 1: Subjects with advanced or metastatic solid tumors who have failed standard therapy or have no standard treatment.

• 8\. Phase 2: A new cohort of subjects with advanced or metastatic solid tumors who have failed or had no standard therapy and are of high prevalence in China, such as non-small cell lung cancer, gastric cancer, and liver cancer, or other solid tumor types with the best clinical response observed from Phase 1 (e.g., CR \> PR \> SD).

‣ For subjects with non-small cell lung cancer: histologically or cytologically confirmed non-small cell lung cancer with mutations or gene amplification in EGFR, MET, or VEGF genes, EGFR or cMET overexpression (refer to IHC≥2+ in the Central Laboratory Immunohistochemistry Antibody Interpretation Criteria, ≥ intermediate staining).

‣ For subjects with gastric cancer: histopathologically confirmed gastric cancer or gastroesophageal junction cancer (including lower esophageal adenocarcinoma) with mutations or gene amplifications in EGFR, MET, or VEGF genes, EGFR or cMET overexpression (IHC≥2+ in reference central laboratory immunohistochemistry antibody interpretation criteria, ≥ moderate staining).

‣ For subjects with hepatocellular carcinoma: histologically or cytologically pathologically confirmed primary hepatocellular carcinoma with mutations or gene amplification in EGFR, MET or VEGF, overexpression of EGFR or cMET (IHC≥2+ in reference central laboratory immunohistochemistry antibody interpretation standards, ≥ moderate staining).

∙ Note: The tumor biopsy test report performed by the subject for other purposes (i.e., not a protocol-defined procedure) within 1 year prior to signing the consent form can be used as the basis for pre-treatment biopsy evaluation, and if metastases or recurrences of other tumors have occurred within 1 year, they are excluded.

∙ 9\. Stage 2: Willing to undergo pre-treatment and end-of-treatment (if appropriate) tumor biopsy (rough needle aspiration or excision) of a tumor tissue sample for biomarker immunohistochemistry and genetic testing.

∙ Note: Tumor biopsy archival tissue samples performed by subjects for other purposes (i.e., not protocol-defined procedures) within 1 year prior to signing the consent form may be used as pre-treatment tumor biopsy tissue samples, excluded if metastases or recurrences of other tumors have occurred within 1 year.

∙ Note: Subjects are required to provide 4-6 blank sections with a layer thickness of 3-5 μm and 10-12 blank sections with a layer thickness of 8-10 μm, or preferably 1 tissue block for EGFR and cMET immunohistochemistry and polygenic mutation/amplification detection. If the amount of tumor tissue obtained is limited, it is important to prioritize the need for EGFR and cMET immunohistochemistry detection (at least 4 blank sections with a layer thickness of 3-5 μm), followed by tumor tissue polygenic detection (10-12 blank sections with a layer thickness of 8-10 μm), and finally FISH detection for EGFR and MET gene amplification of tumor tissue (4-6 blank sections with a thickness of 3-5 μm).

∙ Note: Pre-treatment tumor tissue sections are not mandatory for subjects in Phase 2 if the tumor biopsy test report for other purposes (i.e., not a protocol-defined procedure) within 1 year prior to signing the consent form contains EGFR or cMET immunohistochemistry results. At the end of treatment, it is not suitable for/unwilling to provide tissue samples or other reasons that preclude tumor biopsy, and tumor biopsy is not mandatory.

∙ Note: Tumor tissue samples are optional before and at the end of treatment in Phase 1, and best efforts should be made to obtain tumor tissue if possible. Test results are collected if the subject has had a tumor biopsy for other purposes (i.e., not a protocol-defined procedure) within 1 year prior to signing the consent form, and the test results contain EGFR, cMET, or VEGF.

∙ 10\. For Phase 1 and Phase 2, subjects agree to collect additional peripheral blood for circulating tumor cell DNA (ctDNA) analysis.

∙ 11\. Female subjects of childbearing potential (defined as not undergoing hysterectomy and/or bilateral oophorectomy sterilization surgery and not postmenopausal, menopausal is defined as amenorrhea ≥ 12 months) must have a negative blood pregnancy test at screening.

⁃ All female subjects of childbearing potential must agree to take appropriate precautions to avoid pregnancy (with at least 99% certainty) from screening until 60 days after the last dose of study drug is administered. Male partners of female subjects (other than men who have been sterilized) must agree to use condoms correctly and on a continuous basis for the duration of the study and for 60 days after receiving the last dose of study drug.

⁃ All male subjects (except those who have been sterilized) must agree to take appropriate precautions to avoid pregnancy with their partner (with at least 99% certainty) from screening until 90 days after the last dose of study drug administration. The female partner of male subjects (if of childbearing potential or less than 12 months postmenopausal) must agree to use a highly effective method of contraception for the duration of the study and within 90 days of receiving the last dose of study drug. In addition, sperm donation is not allowed during the study and for 90 days after receiving the last dose of study drug.

⁃ At least 99% effective contraceptive methods (see Appendix A) should be communicated to subjects and their understanding confirmed.

⁃ 12\. All of the following criteria need to be met during the screening period, and if the following screening laboratory tests were performed \> 7 days prior to the start of treatment, they will need to be repeated within 7 days prior to the start of treatment.

∙ a. Absolute neutrophil count ≥ 1.5 ×109/L, platelet ≥ 100 ×109/L, hemoglobin ≥9 g/dL or ≥5.6 mmol/L, and no transfusion of blood products (including platelets or red blood cells) or use of colony-stimulating factors (including granulocyte colony-stimulating factor, Granulocyte macrophage colony-stimulating factor or recombinant erythropoietin) (the washout period of long-acting colony-stimulating factor or erythropoietin is at the discretion of the investigator).

∙ b. AST and ALT≤2.5×Upper limit of normal(ULN)(AST and ALT in subjects with primary or metastatic liver cancer≤5× ULN)。 c. Total bilirubin ≤ 1.5 × ULN (3× ULN for subjects with Gilbert's syndrome ≤), if there is no ULN at the study institution, direct bilirubin must be \< 40% of total bilirubin.

∙ d. Creatinine clearance ≥ 30 mL/min (estimated by the Cockcroft-Gault formula, \[140-age\]× weight (Kg)/serum creatinine (mg/dl) × 72, or \[140-age\]× body weight (Kg)/serum creatinine (μmol/L) × 0.818, calculated × 0.85 for women).

∙ e. International normalized ratio (INR) ≤ 1.5× ULN, activated partial thromboplastin time (APTT) ≤ 1.5×ULN (without anticoagulant); INR ≤2.5×ULN, APTT≤2.5×ULN (those using anticoagulants).

∙ 13\. Human immunodeficiency virus (HIV)/hepatitis B (HBV)/hepatitis C (HCV) subjects will be allowed to participate in the study if the following criteria are met:

⁃ HIV-infected subjects: CD4+ T cell (CD4+) count must be ≥ 350 cells/μL; Subjects with HIV infection-related tumors (e.g., Kaposi's sarcoma and invasive cervical cancer) were allowed to enroll; To ensure that subjects can tolerate effective antiretroviral therapy and that toxicity is not confused with study drug toxicity, subjects should receive at least four weeks of established antiretroviral therapy prior to enrollment and have an HIV viral load of less than 400 copies/mL and require replacement of specific ART drugs that may have overlapping toxicity or interaction with the study drug, and exclusion if no replaceable drug is available.

⁃ Subjects who have no history of hepatitis B infection but have been vaccinated against hepatitis B and have tested positive for hepatitis B surface antibody by serology can participate in the study; HBV virus carriers or subjects with chronic active hepatitis B, whose HBV-DNA copy number is lower than the lower limit of normal in each center after anti-hepatitis B virus treatment, and whose liver function meets the above requirements can participate in the study.

⁃ If the subject is positive for hepatitis C antibody, the HCV-RNA is lower than the lower limit of normal after drug treatment, and the subject is not at risk of hepatic insufficiency, he or she can participate in the study.

⁃ Note: Viral replication and possible interactions and overlapping toxicities of antiviral therapy with the study drug should be closely monitored during the study participation in the above three categories of subjects